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the claim
Negative feedback loops in biological systems can generate sustained oscillations.
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
5 sources for · 0 against

Extensive biological and mathematical modeling demonstrates that negative feedback loops can indeed generate sustained oscillations in various cellular and genetic systems.

Evidence for · 5
Explaining oscillations and variability in the p53-Mdm2 system
2008 · cited by 123
Demonstrates that sustained oscillations emerge directly from negative feedback loops within the p53-Mdm2 biological circuit.
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The analysis

The retrieved papers consistently support the claim that negative feedback loops in biological systems can generate sustained oscillations, citing examples from p53-Mdm2 circuits, gene regulatory networks, and general biochemical models.

More for · 4
Limit cycles in models of circular gene networks regulated by negative feedback loops
2020 · cited by 17
Shows the existence and stability of oscillating trajectories in circular gene networks regulated by negative feedback.
Qualitative control of undesired oscillations in a genetic negative feedback loop with uncertain measurements
2020 · cited by 9
Notes that biological gene regulatory networks modeled by negative feedback loops naturally give rise to sustained oscillations.
Control of negative feedback loops in genetic networks
2020 · cited by 9
Identifies the negative feedback loop of two genes as a classical motif capable of producing sustained oscillations.
Modeling Biological Oscillations: Integration of Short Reaction Pauses into a Stationary Model of a Negative Feedback Loop Generates Sustained Long Oscillations
2019 · cited by 2
Discusses how sustained oscillations are frequently observed and generated in biological systems consisting of a negative feedback loop.
The paper trail · every fact has a biography
first checked31 Jul 2026
judged → SUPPORTED · 8831 Jul 2026
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