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the claim

Naproxen use is contraindicated or harmful in patients with Crohn's disease

the verdict

SUPPORTED

the evidence backs this

confidence 94/100

Evidence indicates that nonsteroidal anti-inflammatory drugs (NSAIDs) such as naproxen can trigger or worsen mucosal damage and inflammation, making them harmful or contraindicated in patients with Crohn's disease.

Evidence for · 2

Adverse Effects of Nonsteroidal Antiinflammatory Drugs: An Update of Gastrointestinal, Cardiovascular and Renal Complications

2014 · cited by 953

Highlights that adverse effects of NSAIDs, including gastrointestinal complications, make them problematic in conditions like inflammatory bowel disease.

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More for · 1

The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut

2002 · cited by 420

Explicitly notes that the administration of nonsteroidal anti-inflammatory drugs is a major risk factor triggering and worsening inflammatory bowel disease like Crohn's disease.

The paper trail · every fact has a biography

first checked02 Aug 2026

judged → SUPPORTED · 9402 Aug 2026

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