Mutations occur during the viral growth phase used to prepare inactivated viral vaccines
the verdict
SUPPORTED
the evidence backs this
confidence 84/100
Mutations can indeed occur and accumulate during the viral growth and passage phases utilized in the preparation of viral vaccines.
Evidence for · 4
Impact of inactivated vaccine on transmission and evolution of H9N2 avian influenza virus in chickens
2025 · cited by 21
Paper 1 notes that viral passage and replication in the context of inactivated vaccine production/usage introduce stable mutations that enhance viral replication.
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More for · 3
Neurovirulence.
1999 · cited by 0
Paper 8 discusses monitoring the reversion of key mutations that accumulate during the manufacture of poliovirus vaccines.
Flucelvax (Optaflu) for seasonal influenza.
2015 · cited by 0
Paper 9 highlights egg-adaptive viral mutations that occur during conventional influenza vaccine manufacturing.
A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine.
2017 · cited by 0
Paper 11 identifies specific viral replication-enhancing mutations introduced during the preparation and high-yield manufacturing of an inactivated Zika vaccine.