Multiple RNA-binding proteins can simultaneously bind to a single mRNA molecule
the verdict
SUPPORTED
the evidence backs this
confidence 83/100
Multiple RNA-binding proteins can and frequently do bind simultaneously to a single mRNA molecule, forming complex messenger ribonucleoprotein (mRNP) particles that cooperatively regulate gene expression.
Evidence for · 2
Single-molecule quantitation of RNA-binding protein occupancy and stoichiometry defines a role for Yra1 (Aly/REF) in nuclear mRNP organization
2023 · cited by 16
This study uses single-molecule imaging to demonstrate that multiple copies of various RNA-binding proteins (such as Yra1, Nab2, and Npl3) simultaneously co-occupy individual nuclear mRNA molecules.
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More for · 1
Effective RNA Regulation by Combination of Multiple Programmable RNA-Binding Proteins
2020 · cited by 3
This research shows that combining multiple programmable RNA-binding proteins targeting independent sequences on a single mRNA molecule effectively and cooperatively regulates transcript function.