Computational methodologies such as multiple ligand simultaneous docking (MLSD) explicitly enable the concurrent docking of several ligands or molecular fragments into a single binding site.
The claim states that multiple ligands can be docked to a single molecular target simultaneously. Papers [0] and [8] directly validate this by introducing and applying multiple ligand simultaneous docking (MLSD) strategies designed to model several ligands or fragments binding at once within a single receptor active site. The remaining papers focus on single-ligand docking, ensemble docking, or multi-target drug design, but do not contradict the possibility of simultaneous docking.