Mouthwash formulations, particularly conventional chemical agents like chlorhexidine, can produce adverse side effects, cytotoxicity, and microbial dysbiosis, supporting concerns regarding their health hazards.
Evidence for · 4
<b>Antibacterial and cytotoxic effects of chlorhexidine combined with sodium DNA on oral microorganisms: an <i>in vitro</i> study using</b> <i><b>Dictyostelium discoideum</b></i>.
2025 · cited by 16
Highlights that chlorhexidine mouthwash can cause significant side effects and cytotoxicity.
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More for · 3
Effects of Antiseptic Formulations on Oral Microbiota and Related Systemic Diseases: A Scoping Review.
2025 · cited by 5
Indicates that oral antiseptics can disrupt microbial homeostasis and potentially contribute to systemic health implications.
Comparative Clinical Evaluation of Chamomile, Sage, and Ginger Mouthwashes in Reducing Plaque and Gingival Inflammation.
2026 · cited by 0
Notes that conventional mouthwashes like chlorhexidine possess drawbacks that limit their long-term acceptability, leading to interest in biocompatible alternatives.
Effect of a tea tree oil mouthwash on plaque-induced gingivitis when comparing to chlorhexidine: an exploratory randomised clinical trial.
2026 · cited by 0
States that prolonged use of chlorhexidine is associated with undesirable side effects, motivating the search for safer alternatives.