Molecular machinery targets recombination hotspots to cut chromosomes
the verdict
SUPPORTED
the evidence backs this
confidence 86/100
Multiple studies demonstrate that specialized molecular complexes, such as PRDM9 and associated chromatin remodelers, specifically target and open recombination hotspots to facilitate chromosomal DNA cutting and meiotic recombination.
Evidence for · 5
HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots
2019 · cited by 57
HELLS and PRDM9 act as a pioneer complex that opens chromatin at recombination hotspots to permit access for the DNA double-strand break machinery.
See more details
More for · 4
Dynamic changes in histone lysine lactylation during meiosis prophase I in mouse spermatogenesis.
2025 · cited by 18
Histone modifications such as H4K8la associate closely with recombination hotspots where DNA double-strand break processing machinery engages.
Molecular mechanisms for environmentally induced and evolutionarily rapid redistribution (plasticity) of meiotic recombination
2021 · cited by 17
DNA site-dependent hotspots modulate rates of recombination and directly promote the activity of the basal recombination machinery including the Spo11/Rec12 complex.
PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish.
2025 · cited by 11
PRDM9 targets recombination hotspots away from promoters and directs meiotic DNA double-strand breaks in vertebrates.
Mechanism of in vivo activation of the MutLγ-Exo1 complex for meiotic crossover formation
2019 · cited by 5
Recombination machinery such as the MutLgamma complex associates directly with DNA double-strand break hotspots during meiotic crossover formation.