Molecular knots possess a defined absolute configuration
Molecular knots can be synthesized stereoselectively to possess defined topological handedness and absolute configuration.
The retrieved papers provide robust evidence from multiple studies showing that molecular knots can be synthesized with defined stereochemistry, chirality, and topological handedness.
Leigh DA, Pirvu L, Schaufelberger F. Stereoselective Synthesis of Molecular Square and Granny Knots.. 2019. https://doi.org/10.1021/jacs.9b01819
Demonstrates the stereoselective synthesis of molecular square and granny knots with specific handedness.
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Tang H, Zou Y, Zhang HN, Jin GX. Stereoselective construction of coconformational mechanically helical and topologically chiral [2]catenanes induced by point chirality.. 2025. https://doi.org/10.1073/pnas.2426356122
Discusses chiral mechanically interlocked molecules including knots and catenanes existing as single enantiomers.
Zhong J, Sun Z, Zhang L, Whitehead GFS, Vitorica-Yrezabal IJ, Leigh DA. Folding a Molecular Strand into a Trefoil Knot of Single Handedness with Co(II)/Co(III) Chaperones.. 2024. https://doi.org/10.1021/jacs.4c05953
Reports the synthesis of a right-handed trefoil knot of single topological handedness governed by stereocenters.
Ma B, Sun Y, Tian H, Zhang X, Ju Y, Gao S, Wu L. Stereoselective Synthesis of Topologically Chiral Knots and Links: Synthesis and Applications.. 2026. https://doi.org/10.3390/molecules31111953
Reviews the stereoselective synthesis of topologically chiral knots where handedness is encoded in an entangled framework.
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