Methylation from DNA gets copied to RNA during transcription
the verdict
REFUTED
the evidence says no
refutedsupported
the weight of evidence
0 sources for · 1 against
AS REPORTEDno primary record reached; this is what the reporting says
The retrieved evidence indicates that DNA methylation typically occurs on a part of the cytosine base that does not interfere with base-pairing during transcription, meaning methylation marks are not directly copied from DNA to RNA.
# Can methylation from DNA get copied to RNA during transcription?
Tags: dna, rna, epigenetics, transcription
- Score: 15
- Views: 476
- Answers: 2
- Answered: yes
- Asked by: Garima Kushwaha (151 rep)
- Asked: 2012-03-08
- Edited: 2012-03-09
- Site: biology
## Question
Methylation on gene-body and 3'UTRs if copied to mRNA can potentially regulate post-transcription modifications or expression regulation. But I'm not sure if they are maintained after transcription or if they get all de-novo methylation.
## Answers
### Answer by bobthejoe (score: 10)
I don't believe anything should change in the majority of DNA-RNA transcription. DNA methylation typically occurs on the non-watson crick side of Cytosine so it shouldn't affect the base-pairing.
However, there are a few hypothetical situations that would result in alterations of the transcribed RNA. The sponatneous deamination of the 4' amine would convert the base into uracil. If there is an additional 5' methyl, the 5-methyluracil would be recognized as Thymine.
(edit) I've talked with several genomics folks about this topic and it turns out that M5Cytosine is very resistant to deamination due to the presence of the Methyl g