Methadone is prescribed as a single-agent opioid agonist for opioid use disorder rather than in combination with naloxone, which is typically combined with buprenorphine or used independently to reverse overdoses.
The claim states that methadone is not prescribed combined with naloxone for opioid use disorder. The retrieved literature consistently treats methadone as a standalone single-agent medication (often contrasted with buprenorphine/naloxone combinations) and identifies naloxone as either a standalone antagonist or combined specifically with buprenorphine. Therefore, the supporting papers uniformly validate the claim that methadone and naloxone are not combined clinically.