Maternal immune tolerance prevents the rejection of the fetus
the verdict
SUPPORTED
the evidence backs this
confidence 79/100
Extensive immunological and clinical evidence demonstrates that maternal immune tolerance is essential to prevent the rejection of the semi-allogeneic fetus during a successful pregnancy.
Evidence for · 5
Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth
2023 · cited by 3
Paper 0 notes that the disruption of maternal immune tolerance is associated with pregnancy complications such as preterm birth.
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More for · 4
TIGIT-Fc Promote Immune Tolerance at the Feto-maternal Interface
2019 · cited by 3
Paper 1 demonstrates that promoting immune tolerance at the feto-maternal interface via regulatory pathways is critical for successful pregnancy.
Perinatal Immune Adaptation and Tolerance at the Maternal–Fetal Interface: A Systematic Review
2025 · cited by 0
Paper 2's systematic review confirms that pregnancy requires the maternal immune system to tolerate the semi-allogeneic fetus.
Inflammatory Burden–Driven Bistability of Maternal–Fetal Immune Tolerance: A Framework for Pregnancy Complications
2026 · cited by 0
Paper 3 outlines the necessity of maternal-fetal immune tolerance to maintain a semi-allogeneic fetus while preventing complications.
Inflammatory Load-Driven Bistability of Maternal–Fetal Immune Tolerance: A Unified Framework for Pregnancy Complications
2026 · cited by 0
Paper 4 states that maternal tolerance of the semi-allogeneic fetus is fundamental to a successful pregnancy.