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the claim

Marijuana consumption induces anxiety through cannabinoid receptor activation in the amygdala

the verdict

SUPPORTED

the evidence backs this

confidence 87/100

Clinical and neuroimaging studies show that acute marijuana (THC) consumption induces anxiety and modulates amygdala function through the activation of cannabinoid-1 (CB1) receptors.

Evidence for · 2

Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors

2017 · cited by 76

Human imaging demonstrates that acute THC administration induces anxiety and alters amygdala activation, and these effects are positively correlated with local CB1 receptor availability.

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More for · 1

Epigenetic Mediation of AKT1 rs1130233’s Effect on Delta-9-Tetrahydrocannabinol-Induced Medial Temporal Function during Fear Processing

2021 · cited by 6

Experimental administration of THC in humans causes increased anxiety and elevated amygdalar activation, supporting the link between cannabinoid receptor mechanisms and anxiogenic responses.

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first checked01 Aug 2026

judged → SUPPORTED · 8701 Aug 2026

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