The HYDROPTIMET case studies (9–10 June 2000 Catalogne, 8–9 September 2002 Cevennes and 24–26 November 2002 Piemont) appear to encompass a sort of prototype flash-flood situations in the western Mediterranean attending to the relevant synoptic and mesoscale signatures identified on the meteorological charts. In Catalogne, the convective event was driven by a low-pressure system of relatively small dimensions developed over the mediterranean coast of Spain that moved into southern France. For Cevennes, the main circulation pattern was a synoptic-scale Atlantic low which induced a persistent southerly low-level jet (LLJ) over the western Mediterranean, strengthened by the Alps along its western flank, which guaranteed continuous moisture supply towards southern France where the long-lived, quasistationary convective system developed. The long Piemont episode, very representative of the most severe alpine flash flood events, shares some similarities with the Cevennes situation during its first stage in that it was controlled by a southerly moist LLJ associated with a large-scale disturbance located to the west. However, these circulation features were transient aspects and during the second half of the episode the situation was dominated by a cyclogenesis process over the Mediterranean which gave place to a mesoscale-size depression at surface that acted to force new heavy rain over the slopes of the Alps and maritime areas. That is, the Piemont episode can be catalogued as of mixed type with regard to the responsible surface disturbance, evolving from a large-scale pattern with remote action (like Cevennes) to a mesoscale pattern with local action (like Catalogne). A prominent mid-tropospheric trough or cut-off low can be identified in all events prior and during the period of heavy rain, which clearly served as the precursor agent for the onset of the flash-flood conditions and the cyclogenesis at low-levels. Being aware of the uncertainty in the representation of the upper-level disturbance and the necessity to cope with it within the operational context when attempting to issue short to mid-range numerical weather predictions of these high impact weather events, a systematic exploration of the predictability of the three selected case studies subject to uncertainties in the representation of the upper-level precursor disturbance is carried out in this paper. The study is based on an ensemble of mesoscale numerical simulations of each event with the MM5 non-hydrostatic model after perturbing in a systematic way the upper-level disturbance, in the sense of displacing slightly this disturbance upstream/downstream along the zonal direction and intensifying/weakening its amplitude. These perturbations are guided by a previous application of the MM5-adjoint model, which consistently shows high sensitivities of the dynamical control of the heavy rain to the flow configuration about the upper-level disturbance on the day before, thus confirming the precursor characteristics of this agent. The perturbations are introduced to the initial conditions by applying a potential vorticity (PV) inversion procedure to the positive PV anomaly associated with the upper-level disturbance, and then using the inverted fields (wind, temperature and geopotential) to modify under a physically consistent balance the model initial fields. The results generally show that the events dominated by mesoscale low-level disturbances (Catalogne and last stage of the Piemont episode) are very sensitive to the initial uncertainties, such that the heavy rain location and magnitude are in some of the experiments strongly changed in response to the "forecast errors" of the cyclone trajectory, intensity, shape and translational speed. In contrast, the other situations (Cevennes and initial stage of the Piemont episode), dominated by a larger scale system wich basically acts to guarantee the establishment and persistence of the southerly LLJ towards the southern France