Low-dose and high-dose dexamethasone suppression tests are used to diagnose Cushing's syndrome
Low-dose and high-dose dexamethasone suppression tests are widely utilized as standard clinical diagnostic and screening tools for Cushing's syndrome.
Multiple retrieved papers consistently reference both low-dose and high-dose dexamethasone suppression tests as established methods for diagnosing and differentiating Cushing's syndrome.
Al‐Saadi, Diederich, Oelkers. A very high dose dexamethasone suppression test for differential diagnosis of Cushing's syndrome. 1998. https://doi.org/10.1046/j.1365-2265.1998.00345.x
Refers to the high-dose dexamethasone suppression test as a mainstay in the differential diagnosis of Cushing's syndrome.
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Palai S, Sahoo BK, Mishra S, Mishra S, Pattanaik S, Jena D. Ectopic Cushing Syndrome Secondary to Corticotropin-secreting Wilms Tumor: A Rare Paraneoplastic Phenomenon.. 2026. https://doi.org/10.1210/jcemcr/luaf325
Notes the absence of cortisol suppression following low- and high-dose dexamethasone suppression tests in diagnosing ectopic Cushing syndrome.
Chasan O, Besisik Terzioglu MB, Mutlu U, Dolen Burak D, Hacisahinogullari H, Gul N, Soyluk Selcukbiricik O, Kubat Uzum A, Yenidunya Yalin G. Prognostic nutritional index and inflammatory indices as predictors of perioperative infection in patients with Cushing syndrome: a retrospective single-center study.. 2026. https://doi.org/10.3389/fendo.2026.1798032
Evaluates the 1-mg dexamethasone suppression test (DST) as a predictor and diagnostic index in Cushing syndrome patients.
Rivera-Martínez WA, Builes-Montaño CE, Román-González A, Builes-Barrera CA, Ramírez-Castaño MJ, Gutiérrez-Restrepo J. Differential diagnosis of ACTH-dependent Cushing's syndrome: Biochemical, imaging, and predictive approaches.. 2026. https://doi.org/10.1016/bs.vh.2026.03.002
Reviews initial laboratory tests including low-dose dexamethasone suppression and high-dose suppression for the differential diagnosis of Cushing's syndrome.
Jack Klahr, Ty Brian Carroll, Robert Nerenz, Hershel Raff. SUN-067 The Reflex Dexamethasone Suppression Test: Development and Assessment of Reflexed Serum Dexamethasone Measurement for the Diagnosis of Cushing Syndrome. 2025. https://doi.org/10.1210/jendso/bvaf149.1652
Discusses the overnight 1 mg dexamethasone suppression test as a screening tool for Cushing syndrome.
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