Long-term potentiation is definitively linked with brain plasticity
the verdict
SUPPORTED
the evidence backs this
confidence 86/100
Long-term potentiation (LTP) is widely recognized and extensively evidenced as a foundational mechanism of brain plasticity, supporting learning, memory, and structural remodeling across neural circuits.
Paper [0] demonstrates how manipulating long-term potentiation and depression directly governs neural competition and memory encoding.
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More for · 11
AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases
2025 · cited by 48
Paper [1] reviews how AMPA receptor trafficking mediates both forms of synaptic plasticity and memory function.
Rapid Estrogenic and Androgenic Neurosteroids Effects in the Induction of Long-Term Synaptic Changes: Implication for Early Memory Formation
2020 · cited by 30
Paper [2] shows that neurosteroids regulate long-term potentiation and depression, which are crucial for neural circuit plasticity.
Mice deficient in synaptic protease neurotrypsin show impaired spaced long-term potentiation and blunted learning-induced modulation of dendritic spines
2023 · cited by 12
Paper [3] links neurotrypsin deficiency to impaired long-term potentiation and disrupted dendritic spine modulation.
The interaction between cannabinoids and long‐term synaptic plasticity: A survey on memory formation and underlying mechanisms
2024 · cited by 8
Paper [4] outlines synaptic plasticity, including long-term potentiation, as foundational for memory and cognitive maintenance.
Dendritic spine neck plasticity controls synaptic expression of long-term potentiation
2023 · cited by 3
Paper [5] uses computational modeling to show how spine neck properties mechanistically regulate long-term potentiation.
D1/D5 receptor activation promotes long‐term potentiation and synaptic tagging/capture in hippocampal area CA2
2025 · cited by 1
Paper [6] establishes that dopamine D1 receptor activation primes area CA2 for long-term potentiation and synaptic plasticity.
A TREK-1/AQP4/TRPA1/BDNF Signaling Axis Is Associated With Astrocytic Volume Transients, Synaptic Plasticity, and Spatial Memory.
2026 · cited by 0
Paper [7] links astrocytic volume transients and BDNF signaling to the modulation of long-term potentiation and synaptic plasticity.
Long-term potentiation in the brain: a synaptic memory mechanism.
2026 · cited by 0
Paper [8] comprehensively reviews long-term potentiation as a core mechanism of neuroplasticity and memory.
Biphasic synaptic plasticity of the medial thalamic-cingulate pathway contributes to pain hypersensitivity in vivo.
2026 · cited by 0
Paper [9] identifies long-term potentiation and depression in the thalamus-ACC pathway as key mechanisms of central synaptic plasticity.