Long-term caffeine use affects human memory
Long-term or chronic caffeine use impacts human cognitive function and memory performance, with studies showing both potential neuroprotective benefits and specific memory impairments depending on the context and timing of consumption.
The retrieved literature contains multiple studies investigating how caffeine and chronic caffeine intake affect brain health, cognition, and memory consolidation, supporting the general claim that long-term or regular caffeine use affects human memory.
Carbone MG, Pagni G, Tagliarini C, Maremmani I, Maremmani AGI. Caffeine in Aging Brains: Cognitive Enhancement, Neurodegeneration, and Emerging Concerns About Addiction.. 2025. https://doi.org/10.3390/ijerph22081171
Caffeine in aging brains: cognitive enhancement, neurodegeneration, and emerging concerns about addiction (2025) notes that prolonged caffeine use and chronic exposure induce neuroadaptive changes and can lead to cognitive impairment or affect memory in older populations.
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Oliveros A, Loncar I, Mostafa M, Poleschuk M, Corujo AM, Qin B, Song J, Tischfield MA, Jang MH. Caffeine attenuates cisplatin induced microglial reactivity and cognitive dysfunction.. 2026. https://doi.org/10.3389/fnmol.2026.1772430
Caffeine attenuates cisplatin induced microglial reactivity and cognitive dysfunction (2026) shows that caffeine confers protection against memory impairments and cognitive deficits in a mouse model.
Boscaini S, Bastiaanssen TFS, Moloney GM, Bergamo F, Zeraik L, O'Leary C, Ferri A, Irfan M, van der Rhee M, Lindemann TIF, Schneider E, Meyyappan AC, Harold KB, Long-Smith CM, Carbia C, O'Riordan KJ, de Alvarenga JFR, Tosi N, Del Rio D, Rosi A, Bresciani L, Mena P, Clarke G, Cryan JF. Habitual coffee intake shapes the gut microbiome and modifies host physiology and cognition.. 2026. https://doi.org/10.1038/s41467-026-71264-8
Habitual coffee intake shapes the gut microbiome and modifies host physiology and cognition (2026) demonstrates that habitual coffee intake is associated with differences in memory performance.
Leon CS, Lo Celso AL, Guajardo RA, Forcato C. Caffeine reduces accuracy in face recognition memory consolidation.. 2025. https://doi.org/10.1038/s41598-025-11737-w
Caffeine reduces accuracy in face recognition memory consolidation (2025) finds that post-encoding caffeine consumption impacts face recognition memory consolidation, resulting in a general impairment in recognition performance.
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