Living organisms excrete nitrogenous wastes to maintain metabolic homeostasis.
Living organisms excrete nitrogenous wastes such as urea and ammonia to maintain metabolic and internal homeostasis.
The retrieved papers consistently demonstrate across various species—including microorganisms, fish, invertebrates, and mammals—that the excretion and clearance of nitrogenous wastes are fundamental mechanisms for maintaining metabolic, acid-base, and ionic homeostasis.
N Yoshida, E P Camargo. Ureotelism and ammonotelism in trypanosomatids. 1978. https://doi.org/10.1128/jb.136.3.1184-1186.1978
Demonstrates that trypanosomatids excrete nitrogenous wastes like urea and ammonia to manage physiological processes.
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F. I. Iftikar, M. Patel, Y. K. Ip, C. M. Wood. The influence of feeding on aerial and aquatic oxygen consumption, nitrogenous waste excretion, and metabolic fuel usage in the African lungfish, Protopterus annectens. 2008. https://doi.org/10.1139/z08-052
Examines nitrogenous waste excretion alongside metabolic fuel usage in lungfish.
David H Evans, Peter M Piermarini, Keith P Choe. The multifunctional fish gill: dominant site of gas exchange, osmoregulation, acid-base regulation, and excretion of nitrogenous waste.. 2005. https://doi.org/10.1152/physrev.00050.2003
Highlights the fish gill as a primary site for nitrogenous waste excretion in maintaining homeostasis.
Martine G E Knol, Vera C Wulfmeyer, Roman-Ulrich Müller, Markus M Rinschen. Amino acid metabolism in kidney health and disease.. 2024. https://doi.org/10.1038/s41581-024-00872-8
Describes how renal amino acid metabolism and nitrogen clearance act as a central hub for metabolic homeostasis.
Biff F Palmer, Deborah J Clegg. Starvation Ketosis and the Kidney.. 2021. https://doi.org/10.1159/000517305
Discusses how the body adapts nitrogen excretion during starvation to maintain homeostasis.
Dirk Weihrauch, Garett Joseph, Garett J P Allen. Ammonia excretion in aquatic invertebrates: new insights and questions.. 2018. https://doi.org/10.1242/jeb.169219
Notes that invertebrates utilize ammonia excretion and homeostasis strategies to survive diverse aquatic environments.
Matthew Nitzahn, Gerald S Lipshutz. CPS1: Looking at an ancient enzyme in a modern light.. 2020. https://doi.org/10.1016/j.ymgme.2020.10.003
Explains how the mammalian urea cycle siphons catabolic waste nitrogen into urea for excretion to prevent toxicity and maintain homeostasis.
Rafael M Duarte, Chris M Wood, Adalberto L Val, D Scott Smith. Physiological protective action of dissolved organic carbon on ion regulation and nitrogenous waste excretion of zebrafish (Danio rerio) exposed to low pH in ion-poor water.. 2018. https://doi.org/10.1007/s00360-018-1169-y
Investigates the nitrogenous waste excretion of zebrafish to assess ionoregulatory homeostasis.
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