trustme.bro/r/…
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the claim
Lipid-soluble substances diffuse directly through the phospholipid bilayer of cell membranes.
the verdict
COMMON KNOWLEDGE
no citation needed for this one
refutedsupported
the weight of evidence
no sources on either side

The claim that lipid-soluble and small passive molecules diffuse directly through the phospholipid bilayer is a fundamental biological principle supported by general scientific knowledge and membrane transport studies.

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The analysis

The claim is a standard, well-established biological fact regarding membrane permeability and simple diffusion. Although many retrieved papers deal with materials science, drug delivery, or specific nanoparticle/protein interactions, paper 6 supports the concept of passive transport directly through the phospholipid bilayer for water molecules.

Everything we examined (12)
We also searched for evidence AGAINST this claim, not only for it.
  1. Insight on passivity of high entropy alloys: Thermal stability and ion transport mechanisms in the passive oxide film on CoCrFeMnNi surfacespeer-reviewedno side takennot shown: read and judged not to bear on this claim
  2. Ion transport mechanisms in the passive film formed on 304L stainless steel studied by ToF-SIMS with 18O isotopic tracerpeer-reviewedno side takennot shown: read and judged not to bear on this claim
  3. Molecular dynamics simulations on the interactions between nucleic acids and a phospholipid bilayerpeer-reviewedno side takennot shown: read and judged not to bear on this claim
  4. Single-Molecule and Super-Resolution Diffusion Quantification Unveils Reversible Enhancement of Lipid-Membrane Diffusivity by General Anesthetics.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  5. Passive Membrane Transport Analysis of Drug Mixturespeer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. Carbon Dots and Biomimetic Membrane Systems: Mechanistic Interactions and Hybrid Nano-Lipid Platforms.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. Steady-state water exchange in neural tissue is primarily passive and through the phospholipid bilayerpeer-reviewedsupportsnot shown: read and graded, but this claim needs no citation to stand
  8. Martini 3 Metabolome.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  9. Decoding Cyclodextrins in Skin Applications: Structure, Mechanisms, and Safety in Cosmetic and Dermatologic Formulations (Part I).peer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. Detergent Conjugation Decouples Chlorpromazine Solubility from Antibacterial Activity against Bacteria Relevant for Gut Microbiota.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  11. Construction of Peptide Amphiphile-Coated Coacervates with Selective Permeability.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  12. Transport pathways across the blood-brain barrier for waste clearance and drug delivery.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked06 Aug 2026
judged → COMMON KNOWLEDGE · 006 Aug 2026
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