Leucovorin rescue selectively protects normal cells without stimulating tumor growth.
the verdict
SUPPORTED
the evidence backs this
confidence 87/100
Leucovorin rescue selectively protects normal cells from high-dose methotrexate toxicity by restoring folate-dependent pathways without reducing the antineoplastic efficacy against tumor cells.
Evidence for · 2
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.
1987 · cited by 76
Evaluates the biochemical basis and metabolic selectivity of leucovorin rescue in relation to antifolate treatment.
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More for · 1
Long-duration intracavitary infusion of methotrexate with systemic leucovorin protection in patients with malignant effusions.
1981 · cited by 76
Demonstrates that leucovorin administration provides systemic protection against high-dose methotrexate toxicity without diminishing the therapeutic exposure of malignant cells.