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the claim
Larger diameter myelinated axons have greater conduction velocities than small diameter myelinated axons
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
4 sources for · 0 against

Established neurophysiological principles and reviews confirm that larger diameter myelinated axons exhibit greater conduction velocities than smaller diameter myelinated axons.

Evidence for · 4
Determinants of conduction velocity in myelinated nerve fibers
1980 · cited by 561
Reviews physiological determinants of conduction velocity and notes that for geometrically similar fibers, conduction velocity is nearly proportional to diameter.
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The analysis

The claim is a well-established physiological principle stating that larger diameter myelinated axons have greater conduction velocities than smaller ones. Multiple reviews and empirical studies in the provided literature (such as papers 0, 3, 6, and 8) explicitly support this relationship via saltatory conduction dynamics and geometric properties. There are no papers contradicting this claim.

More for · 3
Molecular regulators of nerve conduction - Lessons from inherited neuropathies and rodent genetic models.
2015 · cited by 38
Discusses how the geometric dimensions of myelinated nerve fibers, including axon diameter and myelin thickness, affect nerve conduction velocity.
Interplay between MRI-based axon diameter and myelination estimates in macaque and human brain
2025 · cited by 6
Notes that axon diameter and myelin thickness affect the conduction velocity of action potentials in the nervous system according to established structure-function relationships.
Axonal structure-function relationships across experimental modalities
2025 · cited by 3
Explores the structure-function relationship of myelinated nerve fibers linking axon diameter and myelin thickness to conduction velocity via saltatory mechanisms.
Everything we examined (12)
  1. Determinants of conduction velocity in myelinated nerve fiberspeer-reviewedsupports
  2. On the relation between fibre diameter and conduction velocity in myelinated nerve fibrespeer-reviewedno side takennot shown: read and judged not to bear on this claim
  3. The fine structure of muscle spindles in the lumbrical muscles of the rat.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  4. Molecular regulators of nerve conduction - Lessons from inherited neuropathies and rodent genetic models.peer-reviewedsupports
  5. Human intraretinal myelination: Axon diameters and axon/myelin thickness ratiospeer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. The relationship between ischaemic conduction failure and conduction velocity in cat myelinated axonspeer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. Interplay between MRI-based axon diameter and myelination estimates in macaque and human brainpeer-reviewedsupports
  8. Intrinsic and synaptic regulation of axonal excitability in dopaminergic neurons.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  9. Axonal structure-function relationships across experimental modalitiespeer-reviewedsupports
  10. Short-range human cortico-cortical white matter fibers have thinner axons and are less myelinated compared to long-range fibers despite a similar g-ratio.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  11. Synchronization of visual perception within the human fovea.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  12. Biophysical and computational insights from modeling human cortical pyramidal neurons.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked05 Aug 2026
judged → SUPPORTED · 9205 Aug 2026
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