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the claim
Lactate dehydrogenase differentiates exudates from transudates
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
5 sources for · 0 against

Multiple clinical studies confirm that lactate dehydrogenase (LDH) is a standard and effective biomarker used to differentiate between exudative and transudative pleural effusions, both in Light's criteria and in newer fluid-only criteria.

Evidence for · 5
Simplified Criteria Using Pleural Fluid Cholesterol and Lactate Dehydrogenase to Distinguish between Exudative and Transudative Pleural Effusions
2019 · cited by 16
The study evaluates criteria combining pleural fluid lactate dehydrogenase to distinguish between exudates and transudates.
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The analysis

The retrieved papers consistently demonstrate that lactate dehydrogenase (LDH) measurements, whether alone or in combination with other markers such as cholesterol or total protein, are widely used and effective for differentiating between exudates and transudates. No papers refute the claim.

More for · 4
Combined pleural fluid cholesterol and total protein in differentiation of exudates and transudates.
2022 · cited by 16
Pleural fluid lactate dehydrogenase levels are measured along with other parameters to successfully differentiate between exudates and transudates.
Categorisation of pleural fluids in routine clinical practice: analysis of pleural fluid protein and lactate dehydrogenase alone compared with modified Light’s criteria
2008 · cited by 9
Pleural fluid lactate dehydrogenase is used directly in criteria to categorise pleural fluids as either exudates or transudates.
Comparison of the Efficacy of Light’s Criteria With Serum-Effusion Albumin Gradient and Pleural Effusion Glucose
2023 · cited by 5
Pleural fluid lactate dehydrogenase is measured alongside protein and albumin to accurately categorize pleural effusions as transudates or exudates.
Revisiting Light's criteria: a validated blood-free triple combination matches diagnostic accuracy in over 7000 patients.
2026 · cited by 1
Lactate dehydrogenase is a core component of both double and triple combinations used to distinguish exudative from transudative pleural effusions.
Everything we examined (12)
We also searched for evidence AGAINST this claim, not only for it.
  1. Simplified Criteria Using Pleural Fluid Cholesterol and Lactate Dehydrogenase to Distinguish between Exudative and Transudative Pleural Effusionspeer-reviewedsupports
  2. Combined pleural fluid cholesterol and total protein in differentiation of exudates and transudates.peer-reviewedsupports
  3. Clinical significance of pleural fluid lactate dehydrogenase/adenosine deaminase ratio in the diagnosis of tuberculous pleural effusionpeer-reviewedno side takennot shown: read and judged not to bear on this claim
  4. Categorisation of pleural fluids in routine clinical practice: analysis of pleural fluid protein and lactate dehydrogenase alone compared with modified Light’s criteriapeer-reviewedsupports
  5. Diagnostic utility of LDH measurement for determining the etiology of modified transudate pleural effusion in catspeer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. Comparison of the Efficacy of Light’s Criteria With Serum-Effusion Albumin Gradient and Pleural Effusion Glucosepeer-reviewedsupports
  7. Exploring pleural effusion characterisation with quantitative thoracic ultrasound imaging: a viewpoint on the investigational role of pixel-based echogenicity analysis in transudate and exudate differentiation.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. A 3D genome compendium of breast cancer progression.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  9. Ex-Vivo Drug-Sensitivity Testing to Predict Clinical Response in Non-Small Cell Lung Cancer and Pleural Mesothelioma: A Systematic Review and Narrative Synthesis.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. Protocol for generation and utilization of patient-derived organoids from multimodal specimen.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  11. Revisiting Light's criteria: a validated blood-free triple combination matches diagnostic accuracy in over 7000 patients.peer-reviewedsupports
  12. The impact of the COVID-19 pandemic on the epidemiology, clinical manifestations and molecular characteristics of <i>Mycoplasma pneumoniae</i>.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked06 Aug 2026
judged → SUPPORTED · 8306 Aug 2026
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