Kidney donors eventually undergo glomerular hypertrophy in their remaining kidney
Evidence consistently shows that kidney donors experience compensatory glomerular hypertrophy in their remaining kidney following uninephrectomy.
The retrieved literature, particularly studies addressing single-kidney states following uninephrectomy in living donors, consistently supports the premise that the remaining kidney undergoes compensatory glomerular hypertrophy.
Anne-Lise Kamper, Niels-Henrik Holstein-Rathlou, Svend Strandgaard, Paul Peter Leyssac, Ole Munck. Glomerular Filtration Rate and Segmental Tubular Function in the Early Phase after Transplantation/Uninephrectomy in Recipients and Their Living-Related Kidney Donors. 1994. https://doi.org/10.1042/cs0870519
The study demonstrates that the remaining kidney undergoes compensatory hypertrophy following uninephrectomy in living donors.
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Abhijit S. Naik, Su-qing Wang, Mahboob A Chowdhury, J. Aqeel, Christopher L. O'Connor, J. Wiggins, M. Bitzer, R. Wiggins. Critical timing of ACEi initiation prevents compensatory glomerular hypertrophy in the remaining single kidney. 2021. https://doi.org/10.1038/s41598-021-99124-z
This study investigates compensatory glomerular volume increase after uninephrectomy in single kidney states such as living donation.
Cusick M, Nair V, Fermin D, Hartman J, Beamish JA, Sun Z, Zhang Z, Otto E, Menon R, Nadimidla S, Demchuk N, Shaffer K, Heeger P, Zhang W, Menon MC, Kretzler M, Wiggins RC, Naik AS. The growth hormone/IGF-1 axis is a risk factor for long-term kidney allograft failure.. 2025. https://doi.org/10.1172/jci.insight.188485
The paper discusses early hypertrophic responses and maladaptive hypertrophy in the single kidney state after nephrectomy.
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