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the claim
It is possible to have a negative skin test for tuberculosis and a positive QuantiFERON-TB Gold test
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
5 sources for · 0 against

Clinical studies consistently show that tuberculin skin tests and QuantiFERON-TB blood tests frequently yield discordant results, making it entirely possible to have a negative skin test alongside a positive QuantiFERON test.

Evidence for · 5
Discordance of Tuberculin Skin Test and Interferon Gamma Release Assay in Recently Exposed Household Contacts of Pulmonary TB Cases in Brazil
2014 · cited by 27
Paper [0] demonstrates that among household contacts, a subset of tuberculin skin test negative individuals tested positive on the QuantiFERON test.
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The analysis

The retrieved literature extensively documents instances of discordance between the tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) like QuantiFERON-TB Gold. Numerous studies report patients who are TST-negative but QuantiFERON-positive, confirming the claim. There is no evidence refuting this physiological and diagnostic discrepancy.

More for · 4
Screening for latent tuberculosis in Norwegian health care workers: high frequency of discordant tuberculin skin test positive and interferon-gamma release assay negative results
2013 · cited by 18
Paper [1] reports significant discordance where many healthcare workers with positive tuberculin skin tests had negative QuantiFERON results, and vice versa.
<i>Mycobacterium Tuberculosis</i> Infection, Immigration Status, and Diagnostic Discordance: A Comparison of Tuberculin Skin Test and QuantiFERON®-TB Gold in-Tube Test among Immigrants to the U.S.
2016 · cited by 9
Paper [2] notes higher rates of discordant test results, including positive TST and negative IGRA outcomes, among immigrants.
Utility of QuantiFERON®-TB gold In-Tube test compared with tuberculin skin test in diagnosing tuberculosis in Indian children with malnutrition
2019 · cited by 7
Paper [3] highlights distinct patterns of test discordance, including QuantiFERON-positive/TST-negative results in children.
Positivity rate of QuantiFERON-TB Gold Plus&lt;sup&gt;®&lt;/sup&gt; test among candidates for biotherapy and factors influencing results.
2026 · cited by 0
Paper [6] documents weak overall agreement between the simultaneous TST and QuantiFERON-TB Gold Plus tests in a large cohort.
The paper trail · every fact has a biography
first checked04 Aug 2026
judged → SUPPORTED · 8404 Aug 2026
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