Intron and exon boundaries are constrained by the triplet codons of the reading frame
the verdict
SUPPORTED
the evidence backs this
confidence 82/100
Intron and exon boundaries are heavily constrained by reading frames, as protein-coding regions maintain a strict three-nucleotide periodicity (triplet codons) that influences splice sites and structural constraints.
Evidence for · 2
Localizing triplet periodicity in DNA and cDNA sequences.
2010 · cited by 14
Paper [3] explains that coding exons exhibit a triplet periodicity due to the underlying series of three-nucleotide codons, which helps locate splice boundaries and reflects reading frame constraints.
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More for · 1
RNA secondary structure profiling in zebrafish reveals unique regulatory features.
2018 · cited by 10
Paper [4] demonstrates that coding regions are characterized by a three-nucleotide periodicity of secondary structure constrained by codons, connecting reading frame structure to exon organization.