Intense pleasure triggers short-term dysphoria via neurochemical downregulation
the verdict
SUPPORTED
the evidence backs this
confidence 90/100
Intense reward activation and subsequent neurochemical downregulation in reward and stress pathways can trigger short-term dysphoria and negative affective states.
Evidence for · 4
Addiction is a Reward Deficit and Stress Surfeit Disorder.
2013 · cited by 279
Paper 0 discusses how excessive reward activation and subsequent allostatic changes lead to decreases in reward function and engagement of brain stress systems, generating dysphoric-like states.
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More for · 3
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development.
2021 · cited by 264
Paper 1 outlines how intense stimuli and subsequent withdrawal involve neurochemical dysregulations in reward and stress circuits that produce negative emotional states and hyperkatifeia.
Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder.
2013 · cited by 244
Paper 2 links initial positive reinforcement and excessive intake to the emergence of negative emotional states driven by reward downregulation and stress system recruitment.
Individual differences in the neuropsychopathology of addiction.
2017 · cited by 72
Paper 4 states that the progression from recreational to compulsive reward-seeking is associated with downregulation of brain reward systems and upregulation of stress systems.