Inflammatory arthritides symptoms worsen at night and in the morning due to circadian cytokine fluctuations
Multiple studies demonstrate that inflammatory arthritides exhibit worsening symptoms and stiffness at night and in the morning, driven by circadian fluctuations in inflammatory cytokines and clock genes.
The retrieved literature consistently supports the claim that inflammatory arthritis symptoms such as joint stiffness worsen at specific times of day due to circadian variations in proinflammatory cytokines, clock proteins, and related metabolic pathways.
Cimino A, Pat F, Oyebamiji O, Pferdehirt L, Pham CTN, Herzog ED, Guilak F. Programmable chronogenetic gene circuits for self-regulated circadian delivery of biologic drugs.. 2025. https://doi.org/10.1016/j.jconrel.2025.113959
Paper [0] notes that in rheumatoid arthritis, high levels of proinflammatory cytokines peak early in the morning hours, which is reflected by daily changes in joint stiffness.
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Pang A, Pu S, Pan Y, Huang N, Li D. Short-chain fatty acids from gut microbiota restore Th17/Treg balance in rheumatoid arthritis: Mechanisms and therapeutic potential.. 2025. https://doi.org/10.1016/j.jtauto.2025.100316
Paper [2] shows that factors like butyrate exhibit circadian fluctuations that negatively correlate with morning stiffness severity in rheumatoid arthritis.
Wu YJ, Zhang SY, Chen HY, He XR, Yang GR. Circadian Clock: A Regulator of Immunity in Autoimmune Diseases.. 2025. https://doi.org/10.1002/iid3.70246
Paper [5] highlights that circadian rhythms significantly influence autoimmune disease progression and symptom patterns, specifically citing morning joint stiffness in rheumatoid arthritis.
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