Multiple clinical and epidemiological studies support the connection between indoor mold or water-damaged building exposure and Chronic Inflammatory Response Syndrome (CIRS), highlighting multi-system symptoms and immune activation.
Evidence for · 5
Neurophysiological Effects of Chronic Indoor Environmental Toxic Mold Exposure on Children
2003 · cited by 28
Neurophysiological findings in children show that exposure to toxic indoor molds is associated with significant neurological and behavioral deficits.
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More for · 4
Moist and Mold Exposure is Associated With High Prevalence of Neurological Symptoms and MCS in a Finnish Hospital Workers Cohort.
2020 · cited by 17
Exposure to dampness and mold in a hospital cohort is associated with a high prevalence of central and peripheral nervous system symptoms and multi-system illness.
Reversal of Refractory Ulcerative Colitis and Severe Chronic Fatigue Syndrome Symptoms Arising from Immune Disturbance in an HLA-DR/DQ Genetically Susceptible Individual with Multiple Biotoxin Exposures.
2016 · cited by 2
A case report demonstrates that mycotoxin and toxic mold exposure in a genetically susceptible individual leads to chronic inflammatory response syndrome (CIRS) symptoms.
Exposure to Actinobacteria resident in water-damaged buildings and resultant immune injury in Chronic Inflammatory Response Syndrome
2021 · cited by 2
Research outlines how exposure to water-damaged building microbiota, such as Actinobacteria, triggers innate immune activation characteristic of CIRS.
Biomarkers Over Time: From Visual Contrast Sensitivity to Transcriptomics in Differentiating Chronic Inflammatory Response Syndrome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
2025 · cited by 1
A review highlights the reproducibility of the CIRS framework, linking environmentally acquired illnesses and innate immune activation to indoor exposure biomarkers.