Individuals with Down syndrome exhibit a lower incidence of certain solid tumors
the verdict
SUPPORTED
the evidence backs this
confidence 82/100
Individuals with Down syndrome demonstrate a significantly lower incidence and risk of developing various solid tumors in adulthood compared to the general population.
Evidence for · 6
The prevalence of solid tumors and hematologic malignancies among patients with Down Syndrome: A systematic review and meta-analysis.
2024 · cited by 10
A systematic review and meta-analysis reports the overall prevalence of solid tumors in Down syndrome, highlighting low baseline prevalence figures such as testicular cancer.
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More for · 5
Inverse Comorbidity between Down Syndrome and Solid Tumors: Insights from In Silico Analyses of Down Syndrome Critical Region Genes
2023 · cited by 9
Discusses the inverse comorbidity between Down syndrome and solid tumors like breast and lung cancers, attributing it to chromosome 21 critical region genes.
Solid Tumor Incidence and Patterns in Individuals With Down Syndrome: A Systematic Review and Meta‐Analysis
2025 · cited by 3
Establishes that individuals with Down syndrome exhibit a distinct pattern of solid tumor occurrence compared to the general population.
Lifetime risk of solid tumors and leukemia in Down Syndrome: a population-based Swedish matched cohort study
2025 · cited by 1
A Swedish population-based cohort study demonstrates that individuals with Down syndrome have a significantly lower overall risk of solid tumors in adulthood.
Vulnerability and Protection: Integrative Literature Review on the Contrasting Risk of Leukemias and Solid Tumors in Down Syndrome
2026 · cited by 0
An integrative literature review concludes that Down syndrome confers protection against solid neoplasms, noting low standardized incidence ratios for several solid tumor types.
CNSC-55. THE RARE INTERSECTION OF TRISOMY 21 AND GLIOBLASTOMA IDH WILD-TYPE: A CASE REPORT
2025 · cited by 0
Notes that primary solid brain tumors, including glioblastomas, are rare in persons with Down syndrome, who are typically less predisposed to these cancers.