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the claim

Individuals with autism have a greater genetic predisposition to psychosis and schizophrenia

the verdict

SUPPORTED

the evidence backs this

confidence 87/100

Multiple large-scale genetic and transcriptomic studies demonstrate a significant genetic overlap and positive genetic correlation between autism spectrum disorder and schizophrenia, supporting the claim that individuals with autism carry a greater genetic predisposition to psychosis.

Evidence for · 6

GeneAnalytics Pathway Analysis and Genetic Overlap among Autism Spectrum Disorder, Bipolar Disorder and Schizophrenia

2017 · cited by 73

Identifies overlapping genes and pathways among autism spectrum disorder, bipolar disorder, and schizophrenia, pointing to shared genetic and neurobiological underpinnings.

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More for · 5

Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders

2021 · cited by 31

Reveals similar transcriptome-wide alterations between autism spectrum disorder and schizophrenia, indicating shared molecular pathobiology.

Shared Genetic Determinants of Schizophrenia and Autism Spectrum Disorder Implicate Opposite Risk Patterns: A Genome-Wide Analysis of Common Variants.

2024 · cited by 23

Reports a significant positive genetic correlation between schizophrenia and autism spectrum disorder, identifying jointly influencing genomic loci and shared developmental gene enrichment.

Disease similarity network analysis of Autism Spectrum Disorder and comorbid brain disorders

2022 · cited by 12

Demonstrates that autism spectrum disorder shares a genetic component and network community with conditions in the schizophrenia spectrum.

Copy number variants in people with autism spectrum disorders and co-morbid psychosis.

2017 · cited by 9

Identifies rare copy number variants and affected genetic regions in individuals dually diagnosed with autism spectrum disorder and psychosis.

Detection of Pleiotropic Genetic Factors and Critical Brain Cell Types Linking Insomnia with Psychiatric Disorders.

2025 · cited by 2

Finds significant genetic correlations and shared loci between autism spectrum disorder, schizophrenia, and other psychiatric conditions.

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first checked01 Aug 2026

judged → SUPPORTED · 8701 Aug 2026

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