Individuals who self-harm perceive pain differently and have altered pain tolerance
Current empirical evidence consistently indicates that individuals who engage in nonsuicidal self-injury exhibit altered pain thresholds, altered sensory attenuation, and distinct neurobiological pain-processing differences compared to healthy controls.
The retrieved literature contains multiple recent empirical studies (e.g., Papers 1, 2, and 5) directly supporting the assertion that individuals engaging in nonsuicidal self-injury experience altered pain perception, abnormal pain thresholds, and distinct neural circuit adaptations related to pain processing. There are no papers contradicting this claim, leading to a verdict of SUPPORTED.
Wu S, Xue Y, Hang Y, Xie Y, Zhang P, Liang M, Zhong Y, Wang C. Nonsuicidal self-injury prediction with pain-processing neural circuits using interpretable graph neural network.. 2025. https://doi.org/10.1080/07853890.2025.2520394
This study utilizes graph neural networks on neuroimaging data and notes that individuals with nonsuicidal self-injury exhibit abnormal pain perception and altered pain-processing neural circuits.
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Lalouni M, Fust J, Bjureberg J, Blomé S, Thompson WH, Jayaram-Lindström N, Kosek E, Hellner C, Ehrsson HH, Kilteni K, Jensen KB. Attenuation of Self-Induced Pain in Women With Nonsuicidal Self-Injury and Healthy Controls.. 2025. https://doi.org/10.1002/ejp.70057
This study finds that individuals engaging in nonsuicidal self-injury display significantly higher pressure pain thresholds and a greater prevalence of sensory attenuation compared to controls.
Zhao G, Zheng J, Li Y, Jin C, Tong S, Zheng M, Jin W, Xu Y, Chen H, Zheng T, Xu H, Zhao K, Wang A. Altered cortical structure and networks associated with psychosocial adversity and pain hyposensitivity in adolescents with non-suicidal self-injury.. 2025. https://doi.org/10.1186/s12888-025-07606-5
This research links adolescent nonsuicidal self-injury to altered pain sensitivity and shows that reduced cortical thickness correlates with differences in pain tolerance.
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