IgE antibodies drive classical allergic hypersensitivity and mast cell activation, whereas IgG antibodies can play a distinct, inhibitory or neutralizing role in modulating these allergic responses.
The retrieved literature directly supports the distinction between IgG and IgE in allergic responses, noting that IgE triggers immediate hypersensitivity through mast cells and basophils, while specific IgG subclasses can act to inhibit or block these pathways.