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the claim
Ibuprofen use causes miscarriage
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
2 sources for · 0 against

Multiple large cohort and registry studies indicate that the use of ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) during early pregnancy is significantly associated with an increased risk of miscarriage or spontaneous abortion.

Evidence for · 2
Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortion
2011 · cited by 153
Evaluated prescription NSAID use in pregnancy and found that ibuprofen use was significantly associated with an increased risk of spontaneous abortion.
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The analysis

Papers [0] and [2] directly investigate the relationship between ibuprofen/NSAID use during pregnancy and spontaneous abortion/miscarriage, concluding that there is a statistically significant positive association. No provided papers refute this relationship.

More for · 1
Use of nonsteroidal antiinflammatory drugs during pregnancy and the risk of miscarriage
2018 · cited by 58
Examined nonsteroidal antiinflammatory drug use in early pregnancy and found an increased risk of miscarriage associated with use around conception.
Everything we examined (12)
  1. Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortionpeer-reviewedsupports
  2. Association Between Incident Exposure to Benzodiazepines in Early Pregnancy and Risk of Spontaneous Abortion.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  3. Use of nonsteroidal antiinflammatory drugs during pregnancy and the risk of miscarriagepeer-reviewedsupports
  4. COVID-19 vaccination in pregnancy.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  5. Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriagepeer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. Risks of miscarriage and inadvertent exposure to artemisinin derivatives in the first trimester of pregnancy: a prospective cohort study in western Kenyapeer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. Gestational Exposure to Nonsteroidal Anti-Inflammatory Drugs and Risk of Chronic Kidney Disease in Childhood.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. Pain management for medical abortion before 14 weeks' gestation.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  9. Local anaesthesia for pain control in first trimester surgical abortion.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. First-trimester use of antiseizure medications and the risk of miscarriage: a population-based cohort studypeer-reviewedno side takennot shown: read and judged not to bear on this claim
  11. Identification of MARK2, CCDC71, GATA2, and KLRC3 as candidate diagnostic genes and potential therapeutic targets for repeated implantation failure with antiphospholipid syndrome by integrated bioinformatics analysis andpeer-reviewedno side takennot shown: read and judged not to bear on this claim
  12. A prospective cohort study examining the association between the periconceptual vaginal microbiota and first-trimester miscarriage in Kenyan womenpeer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked05 Aug 2026
judged → SUPPORTED · 7705 Aug 2026
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