Reference evidence reports that prenatal use of non-steroidal anti-inflammatory drugs, including ibuprofen, is associated with an increased risk of miscarriage.
conception or if NSAID use lasted more than a week. Prenatal aspirin use was similarly associated with an increased risk of miscarriage. However, prenatal use of paracetamol, pharmacologically different from NSAIDs and aspirin, was not associated with increased risk of miscarriage regardless of timing and duration of use.
Conclusion Prenatal use of NSAIDs and aspirin increased the risk of miscarriage. These findings need confirmation in studies designed specifically to examine the apparent association. Introduction
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs in the developed world 1 - 3 and are often used by pregnant women. 4 - 6 Because of their widespread use, any unintended effect could have serious adverse public health consequences. Gastrointestinal and renal effects are among the most widely studied and recognised adverse effects of NSAIDs, but reproductive risk, especially from NSAID use in early pregnancy, has not been systematically evaluated. 7 , 8
A recent Danish case-control study linked pharmacy data with birth registry data. 9 The authors selected women with registry reports of miscarriages as cases and live births as controls. They reported an association between use of prescribed NSAIDs and miscarriage, with odds ratios that ranged from 1.3 (95% confidence interval 0.9 to 1.9) for NSAID use 10-12 weeks before miscarriage to 7.0 (2.8 to 17.7) for NSAID use one week before miscarriage. However, the study had several limitations from the choice of data sources, including incomplete ascertainment of both miscarriages and NSAID use during pregnancy, lack of information on the reasons for NSAID use, and lack of information on important confounders.
We sought to examine the effect of NSAIDs on the risk of miscarriage by analysing existing data from our recently completed, population based, cohort study of risk factors for miscarriage. Participants and methods
We conducted a prospective cohort study of the risk factor
Non-steroidal anti-inflammatory drugs are one of the most common prescribed medications for relieving pain, fever, and inflammation. Most NSAIDs are available without a prescription, and they often consumed by pregnant women for short periods of time to treat mild pain. However, these drugs can cause substantial teratogenic effects. NSAIDs such as aspirin, diclofenac sodium and ibuprofen might cause oligohydramnios (low amniotic fluid) or prenatal renal abnormalities if taken in the late second half of pregnancy. The US Food and Drug Administration (FDA) announced that taking NSAIDs in the period from the fifth month of pregnancy to delivery is not safe. This research was conducted to explore pregnant women's knowledge about NSAIDs during gestation period as well as consumption patterns. This study was conducted during the period from 10/2/2022 to 10/3/2022 in private clinics in Al-Bayda, Al-Quba cities as well as Al -Thawra hospital targeting 250 pregnant women who asked gently to fill in a printed questionnaire. The questionnaire has a variety of questions regarding age, consumption of NSAIDs during pregnancy and awareness about the benefits and risks of these drugs. Our study indicated that 55.6% of the pregnant women were in the range of twenty-two to twenty-nine years old. Half of pregnant women (50%) did consume painkillers (NSAIDs). Aspirin was the most common drug (55%). Forty-five out of 125 were consuming these drugs without prescription (36%). The common reason for
Everything we examined (2)
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