Hyperovulation induction agents increase the natural chance of conceiving twins
the verdict
SUPPORTED
the evidence backs this
confidence 93/100
Clinical evidence consistently demonstrates that hyperovulation induction agents, such as clomiphene citrate, stimulate the development of multiple dominant follicles, thereby significantly increasing the chance of conceiving twins or higher-order multiples compared to natural cycles.
Evidence for · 4
The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance
2016 · cited by 707
Paper [0] highlights that pharmacological ovulation induction achieves good pregnancy rates but warns that multiple pregnancy risks must be managed and discussed with patients.
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More for · 3
Aromatase Inhibitors for Ovulation Induction
2006 · cited by 277
Paper [1] notes that clomiphene citrate carries a significant risk of multiple pregnancy compared to natural cycles.
Optimizing the therapeutic donor insemination cycle.
2026 · cited by 0
Paper [4] finds that the addition of oral ovulation induction agents significantly increases the risk of multiple gestation.
Clomiphene citrate in the management of anovulation: a review of mechanisms, outcomes, and clinical challenges.
2026 · cited by 0
Paper [6] reports a notable risk of multiple pregnancies (8%-10%) associated with clomiphene citrate ovulation induction.