Hydrogen bonding typically causes distinct downfield chemical shifts (deshielding) in nuclear magnetic resonance spectra, a foundational principle widely supported by spectroscopic and computational analyses.
The retrieved literature discusses how hydrogen bonding interactions directly influence nuclear magnetic resonance (NMR) parameters, specifically noting the traditional and well-documented occurrence of downfield chemical shifts (deshielding) upon hydrogen bond formation (e.g., in papers [3], [5], and [9]). While paper [3] notes rare exceptions involving blue-shifting hydrogen bonds that display shielding, the overwhelming spectroscopic consensus and baseline principle confirmed across the evidence is that hydrogen bonding correlates with downfield shifts.