Human chromosome 2 formed from the evolutionary fusion of two ancestral chromosomes.
the verdict
SUPPORTED
the evidence backs this
confidence 90/100
Extensive genomic, cytogenetic, and sequencing evidence confirms that human chromosome 2 originated from the head-to-head fusion of two ancestral chromosomes, explaining the reduction from 48 chromosomes in great apes to 46 in humans.
Evidence for · 6
Origin of human chromosome 2: an ancestral telomere-telomere fusion.
1991 · cited by 285
Identifies telomeric repeats in a head-to-head arrangement at the human chromosome 2 locus, confirming an ancient telomere-telomere fusion.
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More for · 5
Genomic Structure and Evolution of the Ancestral Chromosome Fusion Site in 2q13–2q14.1 and Paralogous Regions on Other Human Chromosomes
2002 · cited by 102
Details the genomic structure of the >600 kb region surrounding the fusion site on human chromosome 2.
Revised time estimation of the ancestral human chromosome 2 fusion.
2022 · cited by 0
Estimates the timing of the ancestral human chromosome 2 fusion using substitution analysis around the fusion site.
Centromere Destiny in Dicentric Chromosomes: New Insights from the Evolution of Human Chromosome 2 Ancestral Centromeric Region.
2017 · cited by 0
Characterizes the relicts of the chromosome 2q ancestral centromere and how the chromosome was stabilized after fusion.
A brief history of human autosomes.
1999 · cited by 0
Notes that the modern human karyotype differs from ancestral primates by specific chromosomal events, including the fusion forming human chromosome 2.
One pedigree we all may have come from - did Adam and Eve have the chromosome 2 fusion?
2016 · cited by 0
Discusses the reduction in chromosome number caused by the head-to-head fusion of two ancestral chromosomes to form human chromosome 2.