n near the site of infection. When the initial infection heals, the virus spreads to sensory nerve cells, where it remains dormant until reactivation occurs [ 1 ]. Recurrence of labial HSV is typically triggered by factors such as stress, trauma from surgery, menstruation or hormonal shifts in women, hyperthermia or infectious febrile ailments, sunlight or ultraviolet rays, and certain drugs, such as corticosteroids, with substantial psychosocial consequences to patients enduring persistent outbreaks [ 2 ]. The regularity of these recurrent outbreaks varies from one individual to another where the infection is generally contagious during times of active replication, but can also spread when symptoms are absent [ 1 ]. The disease progression in recurrent herpes simplex labialis (HSL) typically incorporates multiple stages. During the precursor stage, perceptions of pain, tingling, or burning may transpire in the affected area, followed by the development of vesicles. Rupturing of the vesicle leads to soft scab formation which is subsequently replaced by a hard scab. Periodically, the scab abates and falls off, allowing the lesion to completely heal without scarring. Throughout this healing process, symptoms such as pain and discomfort ensue, and complete healing may require seven to ten days [ 1 , 2 , 3 , 4 ]. 2. Epidemiology Oral HSV-1 infection continually remains exceedingly prevalent and is one of the most common human viral infections throughout the world. According to WHO, an estimated 3.7 billion people under age 50 (67%) have HSV-1 infection globally [ 5 ]. In the United States of America (USA), HSV-1 affects 57% to 80% of adults [ 6 ], while in Asia, the numbers are essentially high for adults (75%) especially those from low socioeconomic standings, and children (50%) due to epidemiological shifts, showing decreased seroprevalence in the young cohorts [ 7 ]. A reported estimate in 2016 revealed that around 3.583 billion were infected with oral HSV totaling a