Housekeeping genes are regulated differently from other genes, often relying on specialized promoter architectures rather than distal enhancers to maintain stable, baseline cellular functions.
The retrieved literature supports the claim that housekeeping genes are regulated through mechanisms distinct from inducible or cell-type-specific genes (such as unique promoter clustering instead of distal enhancers, and distinct genetic organization). Papers [2] and [5] directly address and confirm this difference in regulatory architecture.