trustme.bro/r/…
✓ checked
trust me, bro:
here is the receipt.
the claim
Hormones activating adenylyl cyclase produce diverse cellular effects through distinct downstream signaling pathways.
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
3 sources for · 0 against

Multiple studies demonstrate that hormones and effectors activating adenylyl cyclase generate cyclic AMP, which subsequently engages diverse downstream signaling pathways to regulate cellular functions.

Evidence for · 3
Melanogenic Effects of Maclurin Are Mediated through the Activation of cAMP/PKA/CREB and p38 MAPK/CREB Signaling Pathways
2019 · cited by 54
Demonstrates that hormone- or compound-induced cAMP activation stimulates distinct downstream pathways such as PKA/CREB and MAPK to mediate biological effects like melanogenesis.
See more details
The analysis

The retrieved papers provide robust support for the claim that hormones or related effectors activating adenylyl cyclase (and thus modulating cAMP) trigger diverse downstream cellular signaling pathways (such as PKA, MAPK, and various transcriptional regulators) leading to varied cellular effects.

More for · 2
The Effects of Different Signaling Pathways in Adenylyl Cyclase Stimulation on Red Blood Cells Deformability
2019 · cited by 16
Shows that adenylyl cyclase stimulation and subsequent cAMP elevation activate complex molecular signaling cascades that regulate red blood cell micromechanical properties.
The ulcerative colitis risk gene adenylyl cyclase 7 restrains the T-helper 2 phenotype and Class II antigen presentation.
2025 · cited by 2
Indicates that adenylyl cyclase generates cyclic AMP downstream of GPCR signaling, which in turn influences diverse cellular processes including cytokine production and antigen presentation.
Everything we examined (12)
We also searched for evidence AGAINST this claim, not only for it.
  1. Interplay of oxidative stress, cellular communication and signaling pathways in cancerpeer-reviewedno side takennot shown: read and judged not to bear on this claim
  2. Melanogenic Effects of Maclurin Are Mediated through the Activation of cAMP/PKA/CREB and p38 MAPK/CREB Signaling Pathwayspeer-reviewedsupports
  3. Differential Involvement of the Ras and Rap1 Small GTPases in Vasoactive Intestinal and Pituitary Adenylyl Cyclase Activating Polypeptides Control of the Prolactin Gene*peer-reviewedno side takennot shown: read and judged not to bear on this claim
  4. Probiotics promote cellular wound healing responses by modulating the PI3K and TGF-β/Smad signaling pathwayspeer-reviewedno side takennot shown: read and judged not to bear on this claim
  5. The Effects of Different Signaling Pathways in Adenylyl Cyclase Stimulation on Red Blood Cells Deformabilitypeer-reviewedsupports
  6. Constitutive activity among orphan G protein-coupled receptors: Molecular mechanisms and pharmacological perspectives.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. Sotatercept: A Crosstalk Between Pathways and Activities in the Pulmonary Circulation and Blood.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. The ulcerative colitis risk gene adenylyl cyclase 7 restrains the T-helper 2 phenotype and Class II antigen presentation.peer-reviewedsupports
  9. Structure-Based Insights into TGR5 Activation by Natural Compounds: Therapeutic Implications and Emerging Strategies for Obesity Management.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. β-Adrenergic Receptors: Not Always Outside-In.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  11. Mechanistic basis for the antifibrotic actions of cAMP-based therapies.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  12. Hypercapnia Effects on Lung Function.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked05 Aug 2026
judged → SUPPORTED · 8605 Aug 2026
This receipt carries no identity, shared or not. Sharing publishes your connection to it, not your data.
Check your own claim
Challenge the receipt
trust me, bro: win the argument, pass the class, survive peer review.
This receipt is an automated verdict against our published method · not an opinion about any author or publication.
Terms · Privacy · How verdicts work · Dispute this receipt