Extensive scientific and clinical evidence demonstrates that human immunodeficiency virus (HIV) is the causative agent of acquired immunodeficiency syndrome (AIDS), with antiviral treatments successfully altering disease progression.
Evidence for · 6
A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or Less
1997 · cited by 2,677
This study demonstrates the clinical efficacy of antiretroviral regimens targeting HIV in slowing the progression to AIDS.
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More for · 5
Isolation of HTLV-III from Cerebrospinal Fluid and Neural Tissues of Patients with Neurologic Syndromes Related to the Acquired Immunodeficiency Syndrome
1985 · cited by 1,109
Early research established the isolation of HIV (HTLV-III) from neurological tissues of patients with AIDS-related conditions.
Quantitation of Human Immunodeficiency Virus Type 1 in the Blood of Infected Persons
1989 · cited by 1,078
Quantitation studies showed high levels of HIV viremia in infected individuals, linking viral load directly to disease status.
Transient High Levels of Viremia in Patients with Primary Human Immunodeficiency Virus Type 1 Infection
1991 · cited by 844
Investigations into primary HIV infection documented large viral burdens during the acute phase preceding seroconversion.
Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates
1989 · cited by 639
Studies on sequential HIV isolates indicated that biological properties and replication rates of HIV influence the course of infection toward AIDS.
The first postmodern pandemic: 25 years of HIV/ AIDS
2008 · cited by 218
Reviews of the first 25 years of the pandemic confirm that the scientific community rapidly and successfully identified HIV as the etiology of AIDS.