HindII was the first restriction endonuclease to be extracted

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Evidence establishes that HindII (originally called endonuclease R) was the first restriction endonuclease to be isolated and characterized.

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Evidence for · 2

nature.com: (untitled)

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nature.com: (untitled). nature.com. http://nature.com/articles/miledna04.pdf

States Smith and Wilcox reported the isolation and characterization of the first restriction enzyme (endonuclease R, later HindII).

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biology.stackexchange.com: Which was the first restriction endonuclease to be isolated?

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biology.stackexchange.com: Which was the first restriction endonuclease to be isolated?. biology.stackexchange.com. https://biology.stackexchange.com/questions/112586/which-was-the-first-restriction-endonuclease-to-be-isolated

Notes that the first restriction endonuclease, HindII, was isolated and characterized.

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The paper trail · every fact has a biography

first checked31 Jul 2026

judged → SUPPORTED · 7531 Jul 2026

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