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the claim

HindII was the first restriction endonuclease to be extracted

the verdict

SUPPORTED

the evidence backs this

confidence 75/100

Evidence establishes that HindII (originally called endonuclease R) was the first restriction endonuclease to be isolated and characterized.

Evidence for · 2

nature.com: (untitled)

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States Smith and Wilcox reported the isolation and characterization of the first restriction enzyme (endonuclease R, later HindII).

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biology.stackexchange.com: Which was the first restriction endonuclease to be isolated?

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Notes that the first restriction endonuclease, HindII, was isolated and characterized.

The paper trail · every fact has a biography

first checked31 Jul 2026

judged → SUPPORTED · 7531 Jul 2026

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