High-dose potassium supplementation can lead to elevated blood potassium levels (hyperkalemia), particularly in vulnerable individuals or those with impaired renal function. However, the basic physiological link between heavy potassium loading and increased serum potassium is established medical knowledge not requiring citation.
The claim states that high-dose potassium supplementation without medical supervision can cause hyperkalemia. This is a well-established physiological fact governed by electrolyte homeostasis and kidney function, making it common knowledge. Paper [11] supports this by showing potassium supplementation increases plasma potassium levels in certain experimental conditions, but none of the retrieved papers directly evaluate unsupervised human high-dose potassium supplementation causing hyperkalemia as their primary focus. Thus, the verdict is COMMON_KNOWLEDGE, with supportive biochemical evidence cited where applicable.