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the claim
High concentrations of hydrogen peroxide inhibit or denature catalase
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
2 sources for · 0 against

High concentrations of hydrogen peroxide can inhibit or denature catalase, as supported by classical and kinetic studies demonstrating substrate-induced inactivation at elevated peroxide levels.

Evidence for · 2
1968 · cited by 55
Demonstrates that high substrate concentrations of hydrogen peroxide lead to the formation of inactive catalase species such as Compound II.
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The analysis

The retrieved literature includes foundational kinetic studies (such as papers [1] and [4]) showing that elevated concentrations of hydrogen peroxide lead to the formation of inactive enzyme species and increased inactivation rates (substrate inhibition/denaturation). Therefore, the claim is well supported by the provided evidence.

More for · 1
1925 · cited by 21
Shows that in very high concentrations of peroxide, the spontaneous inactivation rate of catalase increases.
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first checked04 Aug 2026
judged → SUPPORTED · 8604 Aug 2026
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