Having weak A or B blood antigens has clinical implications.
Having weak A or B blood antigens has significant clinical implications, particularly concerning transfusion compatibility and specific variant phenotypes.
The retrieved literature consistently supports the clinical relevance of ABO blood group antigens, including weak phenotypes, highlighting their importance in transfusion medicine, transplantation, and disease association studies.
Eiji Hosoi. Biological and clinical aspects of ABO blood group system. 2008. https://doi.org/10.2152/jmi.55.174
Paper [2] highlights that ABO blood group antigens are essential in transfusion medicine for evaluating donor compatibility and hemocyte lifespan.
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Yoshihiko Kominato, Rie Sano, Yōichirō Takahashi, Akira Hayakawa, Kenichi Ogasawara. Human ABO gene transcriptional regulation. 2020. https://doi.org/10.1111/trf.15760
Paper [7] details how weak phenotypes and alterations in A or B antigens involve specific regulatory variants and pathological conditions such as cancer.
N.M. Thornton, S.P. Grimsley. PROCEEDINGS FROM THE INTERNATIONAL SOCIETY OF BLOOD TRANSFUSION WORKING PARTY ON IMMUNOHAEMATOLOGY, WORKSHOP ON THE CLINICAL SIGNIFICANCE OF RED BLOOD CELL ALLOANTIBODIES, SEPTEMBER 9, 2016, DUBAI: Clinical significance of antibodies to antigens in the ABO, MNS, P1PK, Rh, Lutheran, Kell, Lewis, Duffy, Kidd, Diego, Yt, and Xg blood group systems. 2019. https://doi.org/10.21307/immunohematology-2020-021
Paper [10] confirms that the ABO system is the most clinically important blood group system regarding transfusion safety.
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