Harmful and beneficial stress affect tendons differently
the verdict
SUPPORTED
the evidence backs this
confidence 85/100
Beneficial mechanical stimuli help maintain tendon structure and function, whereas mechanical overload and harmful stress lead to adverse molecular and structural remodeling, such as decreased collagen thermal stability and fiber disorganization.
Evidence for · 2
Mechanical overload decreases the thermal stability of collagen in an in vitro tensile overload tendon model
2008 · cited by 41
Demonstrates that mechanical overload decreases the thermal stability and disrupts the collagen lattice structure of tendons, showing negative structural changes.
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More for · 1
Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement.
2023 · cited by 0
Shows that mechanical impingement and altered strain environments cause adverse remodeling such as excess glycosaminoglycan deposition and collagen disorganization.