Gold catalysts promote addition reactions across carbon-carbon triple bonds through electrophilic activation
the verdict
SUPPORTED
the evidence backs this
confidence 89/100
Gold catalysts promote the addition of various reagents across carbon-carbon triple bonds primarily by acting as strong π-acids that electrophilically activate the alkyne moiety.
Evidence for · 4
Recent Advances in Gold(III) Chemistry: Structure, Bonding, Reactivity, and Role in Homogeneous Catalysis.
2020 · cited by 180
Discusses gold catalysis and its role in coordinating and activating alkynes through electrophilic pathways.
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More for · 3
Alkyne Trifunctionalization via Divergent Gold Catalysis: Combining π-Acid Activation, Vinyl-Gold Addition and Redox Catalysis
2021 · cited by 36
Highlights π-acid activation and vinyl-gold addition mechanisms in alkyne transformations using gold catalysts.
Homogeneous Gold Catalysis for Regioselective Carbocyclization of Alkynyl Precursors.
2023 · cited by 9
Reviews π-activation of alkynes as an imperative topic in homogeneous gold catalysis for forming carbon-carbon bonds.
Collective Total Synthesis of a Unique Class of Liverworts-Derived Cembrane Diterpenoids.
2025 · cited by 2
Notes the use of π-acidic gold catalysts to activate triple bonds in synthetic applications.