Glucocorticoid receptor function correlates with behavioral outcomes
the verdict
SUPPORTED
the evidence backs this
confidence 85/100
Extensive preclinical and clinical evidence demonstrates that glucocorticoid receptor function and sensitivity are directly correlated with behavioral outcomes, particularly regarding stress adaptation, anxiety, and depression-like phenotypes.
Evidence for · 7
Chronic Sleep Disruption induces depression-like behavior in adolescent male and female mice and sensitization of the hypothalamic-pituitary-adrenal axis in adolescent female mice.
2020 · cited by 43
Study links glucocorticoid receptor expression and cellular activation in brain regions to depression-like behaviors following sleep disruption.
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More for · 6
Targeting glucocorticoid receptor signaling pathway for treatment of stress-related brain disorders
2024 · cited by 28
Review highlights how aberrant glucocorticoid receptor signaling translates to altered behavior in stress-related disorders.
The Volatile Oil of Zanthoxylum bungeanum Pericarp Improved the Hypothalamic-Pituitary-Adrenal Axis and Gut Microbiota to Attenuate Chronic Unpredictable Stress-Induced Anxiety Behavior in Rats
2021 · cited by 24
Shows that treatments improving anxiety behavior concomitantly elevate glucocorticoid receptor expression in the hypothalamus.
Glucocorticoid Negative Feedback in Regulation of the Hypothalamic-Pituitary-Adrenal Axis in Rhesus Monkeys With Various Types of Adaptive Behavior: Individual and Age-Related Differences
2019 · cited by 17
Demonstrates that individual differences in glucocorticoid receptor feedback regulation correlate with trait anxiety and depression-like behavior.
Fluoxetine treatment reverses chronic stress-induced promotion on Fk506-binding protein 5 expression and multiple effects on glucocorticoid receptor phosphorylation in the paraventricular nucleus of mice.
2024 · cited by 7
Connects changes in glucocorticoid receptor phosphorylation and coregulators in the paraventricular nucleus to depression-like behaviors and antidepressant responses.
Phenotype-Specific Transcriptomic Responses to Glucocorticoid Signaling in the Prefrontal Cortex and Dorsal Raphe Nucleus Following Chronic Social Stress.
2026 · cited by 0
Finds that chronic stress establishes distinct behavioral phenotypes that shape glucocorticoid-responsive transcriptional programs.
Glucocorticoid Receptor Signaling: Multilevel Organization, Roles in Fetal Development, and Postnatal Outcomes.
2026 · cited by 0
Explains how long-term variation in glucocorticoid receptor sensitivity and axis regulation manifests as differences in stress reactivity and affective trajectories.