GERD refractory to weight loss and PPIs has specific underlying causes
the verdict
SUPPORTED
the evidence backs this
confidence 83/100
Evidence consistently shows that gastroesophageal reflux disease refractory to weight loss and proton pump inhibitors stems from distinct underlying mechanisms, including esophageal hypersensitivity, persistent non-acid reflux, motility disorders, psychological stress, and mechanical junction dysfunction.
Evidence for · 8
Refractory Gastroesophageal Reflux Disease and Functional Heartburn.
2020 · cited by 20
Refractory GERD is evaluated by identifying specific underlying mechanisms through systematic diagnostic testing.
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More for · 7
[Underlying Mechanisms and Management of Refractory Gastroesophageal Reflux Disease].
2015 · cited by 5
Refractory GERD encompasses heterogeneous conditions like esophageal hypersensitivity, non-acid reflux, and functional heartburn.
Diagnosis and Treatment of Refractory Gastroesophageal Reflux Disease (GERD)
2015 · cited by 3
Several distinct mechanisms underlie the etiology and pathophysiology of refractory GERD.
Modern Aspects of Diagnosis and Treatment of Refractory Gastroesophageal Reflux Disease
2022 · cited by 2
Underlying mechanisms of PPI-refractory symptoms include persistent pathological reflux, esophageal hypersensitivity, and functional origins.
Brain-Gut Axis Mechanism of Psychological Stress-Exacerbated Acid Reflux Esophageal Injury: A Multi-Omics Study Based on the PPAR Signaling Pathway and Lipid Metabolism
2026 · cited by 0
Psychological stress contributes to refractory GERD via specific brain-gut axis mechanisms and lipid metabolism disorders.
PPI-Refractory GERD in Systemic Sclerosis Is Driven by Distinct Esophageal and Gastric Motility Abnormalities
2026 · cited by 0
PPI-refractory GERD in systemic sclerosis is driven by distinct, quantifiable esophageal and gastric motility abnormalities.
Belching and Reflux: The Relationship and the Underlying Mechanism.
2026 · cited by 0
Belching acts as an underlying mechanism that can trigger reflux events by increasing intragastric pressure.
Endoscopic Sleeve Gastroplasty Combined With GERDx Endoscopic Full-Thickness Plication for Obesity-Associated Mechanical GERD: A Dual-Mechanism Endoscopic Case Series.
2026 · cited by 0
Obesity-associated refractory GERD is driven by specific mechanical factors such as hiatal hernia and junction dysfunction.