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the claim
Extracellular potassium and calcium ion concentrations alter cellular excitability
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
5 sources for · 0 against

Extracellular potassium and calcium ion concentrations play a fundamental role in maintaining and altering cellular excitability across muscle, neural, and cardiac tissues.

Evidence for · 5
Investigation of the relationship between cell-surface calcium-ion gating and phosphatidylinositol turnover by comparison of the effects of elevated extracellular potassium ion concentration on ileium smooth muscle and pancreas
1976 · cited by 31
Demonstrates that elevated extracellular potassium ion concentration increases cell-surface calcium permeability and subsequent contraction in smooth muscle.
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The analysis

The provided literature extensively establishes that changes in extracellular potassium and calcium ion concentrations or gradients directly affect membrane potential, channel function, and cellular excitability in various tissue types. Multiple papers support this mechanism without conflicting evidence.

More for · 4
Ion gradient-driven bifurcations of a multi-scale neuronal model
2022 · cited by 14
Shows that variations in sodium, calcium, and potassium reversal potentials and gradients cause decreases in neural activity and altered excitability.
Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability
2025 · cited by 1
Indicates that impaired extracellular potassium clearance by astrocytes leads to altered resting membrane potential and reduced neuronal excitability.
Nonlinear dynamics of seizure suppression via optogenetic modulation of neuron-astrocyte interaction.
2026 · cited by 0
Integrates dynamic sodium, potassium, and calcium concentrations to show how extracellular ion regulation directly modulates neuronal excitability and seizure activity.
The exquisite link between potassium homeostasis regulation and cardiovascular health: exploration and analysis.
2026 · cited by 0
Highlights that tightly regulated extracellular and intracellular potassium ions are essential for cardiac electrophysiological stability and excitability.
Everything we examined (12)
  1. Investigation of the relationship between cell-surface calcium-ion gating and phosphatidylinositol turnover by comparison of the effects of elevated extracellular potassium ion concentration on ileium smooth muscle and ppeer-reviewedsupports
  2. Ion gradient-driven bifurcations of a multi-scale neuronal modelpeer-reviewedsupports
  3. Biophysical properties of the membrane influence spike initiation dynamics and neuronal excitability: a focus on Kv1 channels in myelinated axonspeer-reviewedno side takennot shown: read and judged not to bear on this claim
  4. Calcium‐sensing receptor regulates Kv7 channels via Gi/o protein signalling and modulates excitability of human induced pluripotent stem cell‐derived nociceptive‐like neuronspeer-reviewedno side takennot shown: read and judged not to bear on this claim
  5. Hypomagnesemia: A Clinical and Nutritional Update.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. Human Dorsal Root Ganglia Neuronal Cell Line to Study Nociceptive Signaling: A New Pipeline for Pain Therapy.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. GABAB Receptor Modulation of Membrane Excitability in Human Pluripotent Stem Cell‐Derived Sensory Neurons by Baclofen and α‐Conotoxin Vc1.1peer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitabilitypeer-reviewedsupports
  9. Copper (Cu<sup>2+</sup>) Inhibits Voltage-Dependent Ionic Currents While Enhancing Neurotransmitter Release in Bovine Chromaffin Cells.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. Nonlinear dynamics of seizure suppression via optogenetic modulation of neuron-astrocyte interaction.peer-reviewedsupports
  11. The exquisite link between potassium homeostasis regulation and cardiovascular health: exploration and analysis.peer-reviewedsupports
  12. Pathophysiology of homocysteine: insights into ion channel dysfunction.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked05 Aug 2026
judged → SUPPORTED · 8405 Aug 2026
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