Eukaryotic organisms have introns to enable alternative splicing and regulation
the verdict
SUPPORTED
the evidence backs this
confidence 94/100
Eukaryotic organisms possess introns that are removed via pre-mRNA splicing, which is widely documented to enable alternative splicing, expand proteome diversity, and regulate gene expression.
Evidence for · 4
Mechanisms and Regulation of Alternative Pre-mRNA Splicing
2015 · cited by 1,147
States that precursor mRNA splicing provides significant expansion of the functional proteome in eukaryotic organisms via alternative splicing and gene regulation.
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More for · 3
A broad analysis of splicing regulation in yeast using a large library of synthetic introns
2021 · cited by 32
Discusses how introns are shaped in evolution to allow cells to regulate their transcriptome and facilitate alternative splicing.
Alternative RNA splicing in cancer: what about adult T-cell leukemia?
2022 · cited by 6
Explains that alternative splicing allows almost 95% of human protein-encoding genes to produce transcripts with different exon combinations, increasing proteome diversity.
Structural-Functional Dynamics of Group II Introns in Plant Mitochondria: Splicing Diversity-Driven Genome Plasticity and Regulatory Adaptation
2025 · cited by 0
Notes that introns perform critical functions in regulating gene expression through splicing mechanisms, including the regulation of alternative splicing by cis-acting elements.